根据中央建设创新型国家的总体战略目标和国家中长期科技发展规划纲要，结合中国科学院科技布局调整的要求，围绕深圳市实施创新型城市战略，2006年2月，中国科学院、深圳市人民政府及香港中文大学友好协商，在深圳市共同建立中国科学院深圳先进技术研究院（以下简称“深圳先进院”），实行理事会管理，探索体制机制创新。

经过十五年发展，深圳先进院目前已初步构建了以科研为主的集科研、教育、产业、资本为一体的微型协同创新生态系统，由九个研究所（中国科学院香港中文大学深圳先进集成技术研究所、生物医学与健康工程研究所、先进计算与数字工程研究所、生物医药与技术研究所、广州中国科学院先进技术研究所、脑认知与脑疾病研究所、合成生物学研究所、先进材料科学与工程研究所、碳中和技术研究所（筹）），国科大深圳先进技术学院，多个特色产业育成基地（深圳龙华、平湖及上海嘉定）、多支产业发展基金、多个具有独立法人资质的新型专业科研机构（深圳创新设计研究院、深圳北斗应用技术研究院、中科创客学院、济宁中科先进技术研究院、天津中科先进技术研究院、珠海中科先进技术研究院、苏州先进技术研究院、杭州先进技术研究院、武汉中科先进技术研究院、山东中科先进技术研究院）等组成。2018年，深圳先进院获批牵头建设深圳市两大重大科技基础设施：脑解析与脑模拟、合成生物研究，并于2019年在光明科学城破土动工；牵头建设的深圳先进电子材料国际创新研究院、深圳市合成生物学创新研究院、深港脑科学创新研究院三大基础研究机构均已在2019年正式揭牌成立。

In accordance with the overall strategic goal of the central government to build an innovative country and the outline of the National Medium - and long-term Plan for Science and Technology Development, and the requirements of the Chinese Academy of Sciences for the adjustment of science and technology layout, the Chinese Academy of Sciences, the Shenzhen Municipal People's Government and the Chinese University of Hong Kong held friendly consultations in February 2006. The Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences (hereinafter referred to as "Shenzhen Institute of Advanced Technology") was jointly established in Shenzhen under the management of the Board of Directors, and institutional innovation was explored.

After 15 years of development, SDI has initially built a micro-collaborative innovation ecosystem integrating scientific research, education, industry and capital. It consists of nine institutes (Shenzhen Institute of Advanced Integrated Technology, Chinese University of Hong Kong, Chinese Academy of Sciences, Institute of Biomedical and Health Engineering, Institute of Advanced Computing and Digital Engineering, Institute of Biological Medicine and Technology, Institute of Advanced Technology, Guangzhou Chinese Academy of Sciences, Institute of Brain Cognition and Brain Diseases, Institute of Synthetic Biology, Institute of Advanced Materials Science and Engineering, and Carbon Neutral Technology Institute (preparation)), UAS Shenzhen Institute of Advanced Technology, A number of characteristic industry cultivation bases (Shenzhen Longhua, Pinghu and Shanghai Jiading), multiple industrial development funds, a number of new professional research institutions with independent legal entity qualification (Shenzhen Innovation Design and Research Institute, Shenzhen Beidou Applied Technology Research Institute, China Science and Technology Maker College, Jining China Science and Technology Research Institute, Tianjin China Science and Technology Research Institute, Zhuhai China Science and Technology Research Institute, Su Zhou Institute of Advanced Technology, Hangzhou Institute of Advanced Technology, Wuhan Institute of Advanced Technology, Shandong Institute of Advanced Technology) and so on. In 2018, Shenzhen Advanced Institute was approved to lead the construction of two major scientific and technological infrastructure facilities in Shenzhen: brain analysis and brain simulation, and synthetic biology research, and broke ground in Bright Science City in 2019. The three major basic research institutions under the leadership of Shenzhen International Innovation Institute of Advanced Electronic Materials, Shenzhen Institute of Synthetic Biology Innovation, and Shenzhen-Hong Kong Institute of Brain Science Innovation have all been officially inaugurated in 2019.