下一代透皮吸收(TDDS)中心于2012年4月成立,是九州大学校长领导下重点推进的新战略研究中心之一。
目前,需要开发微创药物管理技术来取代注射。其中,涂抹、贴附的透皮吸收技术作为患者无痛的下一代药物给药方法备受关注。另一方面,一个人有一个很大的防御功能,特别是角质层,位于皮肤的最外侧,整个皮肤覆盖,以保护自己免受外部侵害。因此,需要特殊技术才能有效地从皮肤中吸收药物。为此,研究人员开发了一种特殊的纳米涂层技术,将药物纳米分散到油基中,从而开发出一种S/O技术。
因此,该中心将利用这种S/O技术,开发新的微创透皮吸收给药方法,以取代微针,这是目前透皮吸收方法的主流,并开发下一代透皮疫苗等。为此,研究人员将整合界面化学、材料化学、生物工程等广泛学科,促进研究,建立国际先进研究中心。该中心将重点促进以纳米技术和生物技术为关键词的基础研究,以及转化研究,以便将获得的新药物发现化合物迅速转化为实际应用和工业化。
特别是,关于TDDS中心的“产业学术合作”部分,研究人员将在伊藤校区附近建立福冈市产业学术合作交流中心(FiaS),以进一步积极促进产业学术合作活动。研究人员已经推出使用S/O技术,并发展到超过4亿日元的年销售额。今后,研究人员将充分利用迄今取得的一系列优秀研究成果,将其推广到药物发现领域。
该中心将提出一种新的透皮吸收给药方法,以取代微针,这是透皮吸收方法的主流,并全面推进医疗材料功能设计研究。促进界面化学、材料化学、生物工程等广泛学科的研究,努力发展成为下一代透皮药物输送系统开发的国际研究基地。
The Next Generation Transdermal Absorption (TDDS) Center was established in April 2012 as one of the new strategic research centers under the leadership of the President of Kyushu University.
Currently, minimally invasive drug management techniques need to be developed to replace injections. Among them, the transdermal absorption technology of application and adhesion has attracted much attention as a painless next-generation drug delivery method for patients. On the other hand, a person has a great defensive function, especially the stratum corneum, located on the outermost side of the skin, and the entire skin is covered to protect himself from external aggressions. Therefore, special techniques are required to effectively absorb the drug from the skin. To this end, the researchers developed a special nanocoating technology that disperses drug nanometers into an oil base, thus developing an S/O technology.
Therefore, the center will use this S/O technology to develop new minimally invasive transdermal absorption drug delivery methods to replace microneedles, which is currently the mainstream of transdermal absorption methods, and develop next-generation transdermal vaccines, among others. To this end, researchers will integrate a wide range of disciplines such as interface chemistry, materials chemistry, and biological engineering to promote research and establish international advanced research centers. The center will focus on promoting basic research with nanotechnology and biotechnology as keywords, as well as translational research, in order to rapidly translate the new drug discovery compounds obtained into practical applications and industrialization.
In particular, regarding the "Industry-Academic Cooperation" part of the TDDS Center, researchers will establish the Fukuoka City Industry-Academic Cooperation and Exchange Center (FiaS) near the Ito campus to further actively promote industry-academia cooperation activities. Researchers have launched the use of S/O technology and have grown to annual sales of more than 400 million yen. In the future, researchers will make full use of the series of excellent research results achieved so far and promote them to the field of drug discovery.
The center will propose a new transdermal absorption drug delivery method to replace microneedling, which is the mainstream of transdermal absorption methods, and comprehensively advance the functional design of medical materials. We will promote research in a wide range of disciplines such as interface chemistry, materials chemistry, and biological engineering, and strive to develop into an international research base for the development of next-generation transdermal drug delivery systems.