蛋白质组中蛋白质的总和,是一种重要的生物机制,通过编码在基因组中的蛋白质,根据细胞的分化阶段和类型。该中心利用最先进的技术,对蛋白质组进行全面分析,详细描述蛋白质组在发育、疾病等过程中的变化,并阐明各种蛋白质组修饰及其调节器组成的控制网络。此外,了解网络崩溃导致癌症等疾病的过程,探索人为修复和修改的方法,并将其用于治疗和药物发现。与国内外相关基地和项目合作,为九大全球研究与教育基地的发展做出贡献。
蛋白质组是构成人体的单个细胞具有的蛋白质总量,它控制细胞类型的特定功能。也就是说,如果基因组是计算机的蓝图,则蛋白质体相当于电路的元件。当蛋白质酶体破裂时,它会导致癌症和其他疾病。
该中心利用超高灵敏度质谱仪的尖端技术,建立了团队内部合作系统,全面分析蛋白质组在发育和疾病等过程中的变化(包括信息学),并开展校内外联合使用和联合研究,旨在阐明由蛋白质修饰、蛋白质结构等组成的蛋白质组控制网络。此外,了解网络崩溃导致癌症和生活方式相关疾病等疾病的过程,探索人为修复和修改的方法,并将其用于癌症治疗、再生医学、药物发现等。
The sum of proteins in the proteome is an important biological mechanism by encoding proteins in the genome, depending on the stage and type of differentiation of cells. The center uses state-of-the-art technology to conduct a comprehensive analysis of the proteome, describe in detail the changes in the proteome during development, disease, etc., and elucidate the control network composed of various proteome modifications and their regulators. Also, understand the processes by which network crashes lead to diseases such as cancer, explore ways to repair and modify them, and use them for treatment and drug discovery. Cooperate with relevant bases and projects at home and abroad to contribute to the development of nine global research and education bases.
The proteome is the total amount of protein that the individual cells that make up the body have, and it controls specific functions of the cell type. That is, if the genome is the blueprint of a computer, the proteosome is equivalent to the element of a circuit. When the proteasome ruptures, it can lead to cancer and other diseases.
Using the cutting-edge technology of ultra-high-sensitivity mass spectrometers, the center has established an internal team cooperation system to comprehensively analyze changes in the proteome in the process of development and disease (including informatics), and carry out joint use and joint research inside and outside the university, aiming to elucidate the proteome control network composed of protein modifications, protein structures, etc. In addition, understand the process by which network crashes lead to diseases such as cancer and lifestyle-related diseases, explore methods of artificial repair and modification, and apply them to cancer treatment, regenerative medicine, drug discovery, and more.