布罗德研究所依靠麻省理工学院和哈佛大学，从两所学校的科学家十年间的研究合作演变而来的。1990年，麻省理工学院基因组研究中心成立，并很快成为基因组学领域的国际领导者和人类基因组计划的旗舰。科学家们认识到有必要将基因组学的力量带入对人类疾病的理解，启动了基因组医学的试点项目，在麻省理工学院和哈佛大学的科学家之间形成了一个非官方的合作网络，开创了癌症和人类遗传学的新方法。
与此同时，哈佛医学院于1998年成立了化学与细胞生物学研究所，以促进化学遗传学作为一门学科的追求，以及进一步了解人类生物学和疾病的工具。2002年发起筛查计划促进了全球80多个研究小组的小分子筛查项目。这些项目需要一种开放、协作、跨学科的组织。麻省理工学院和哈佛大学的基因组科学家和化学生物学家的汇集互补专业知识，2004年成立布罗德研究所，以分子知识推动医学的转型，促进生物医学发展。
布罗德研究所以了解疾病根源、缩小生物学见解和对患者的影响之间的差距为目标，加速生物医学研究和改善人类健康。研究人员深入协作，在各种规模中灵活启动创新项目、发明新技术并构建和实施计算工具，开发新的治疗方法以进入临床，指导和培训下一代科学家，并公开分享我们的数据和工具，帮助实现任何方面的突破。研究送使用系统、公正的方法来识别疾病的根本生物学原因，并找到治疗干预的新机会。通过读取和编辑基因组、共享数据和工具，与行业伙伴、世界各地的科学家以及研究组织合作，免费提供发现、数据、工具、技术和知识，应对生物医学中的重要挑战，并找到创新、高效的解决方案，致力于了解基因组和细胞生物学的基本基础，揭示疾病原因的生物学原理，从而为更精确地监测，诊断和治疗患者提供新的方法。
Relying on MIT and Harvard, the Broad Institute evolved from a decade-long research collaboration between scientists at both schools. In 1990, the MIT Genome Research Center was established and soon became an international leader in genomics and flagship of the Human Genome Project. Recognizing the need to bring the power of genomics into the understanding of human disease, the scientists launched a pilot project in genomic medicine that formed an unofficial collaborative network between scientists at MIT and Harvard University, pioneering new approaches to cancer and human genetics.
Meanwhile, harvard medical school established the Institute of Chemistry and Cell Biology in 1998 to promote the pursuit of chemical genetics as a discipline, as well as tools for further understanding of human biology and disease. Launched in 2002, the Screening Program facilitated small molecule screening projects in more than 80 research groups worldwide. These projects require an open, collaborative, and interdisciplinary organization. Combining complementary expertise among genomic scientists and chemical biologists at MIT and Harvard University, the Broad Institute was established in 2004 to advance biomedicine with molecular knowledge.
Broad Research Institute aims to accelerate biomedical research and improve human health by understanding the root causes of disease and bridging the gap between biological insights and impact on patients. Researchers collaborate deeply, flexibly launch innovative projects, invent new technologies and build and implement computational tools at all scales, develop new treatments to enter the clinic, mentor and train the next generation of scientists, and publicly share our data and tools to help achieve breakthroughs in any area. Research delivers systematic, unbiased methods to identify the underlying biological causes of disease and to identify new opportunities for therapeutic interventions. By reading and editing genomes, sharing data and tools, and collaborating with industry partners, scientists around the world, and research organizations, freely provide discoveries, data, tools, technologies, and knowledge to address important challenges in biomedicine and find innovative, efficient solutions dedicated to understanding the fundamentals of genome and cell biology and revealing the biology of disease causes, thereby providing new ways to more precisely monitor, diagnose, and treat patients.