该实验室的活动旨在研究蛋白质的结构,动力学和功能,它们在人类疾病中的作用,以及开发核磁共振方法的新方法。实验室进行的研究包括:粘蛋白1的细胞质结构域;开发用于研究蛋白质结构和动力学的新型固态核磁共振实验;视紫红质的活化;内在无序蛋白质与其折叠靶标的结合;通过最先进的无约束 MD 仿真改进 NMR 结构
The laboratory's activities are aimed at studying the structure, dynamics and function of proteins, their role in human disease, and developing new methods for NMR methods. Laboratory studies include the cytoplasmic domain of mucin 1; Developing novel solid-state NMR experiments for studying protein structure and dynamics; Activation of rhodopsin; Binding of intrinsic disordered proteins to their folding targets; Improved NMR structure with state-of-the-art unconstrained MD simulation