创新背景

腺苷是人体自然产生的一种生物分子，在刺激骨骼生长方面起着重要作用。

创新过程

研究人员Varghese发现，腺苷是人体自然产生的一种生物分子，在刺激骨骼生长方面起着重要作用。此后，研究团队为外科医生设计了一种绷带，以植入骨折部位，利用身体产生的腺苷，将其保持在受伤部位以加速自然愈合过程。

在此基础上，研究人员还在研究一种非激素小分子药物，该药物可激活相同的生化受体以治疗与骨质疏松症相关的骨质流失。与目前的治疗方法不同，目前只能减缓骨质流失，而研究小组测试的药物已经在动物研究中显示出逆转它并刺激身体重建骨骼的能力。

研究团队还开发了一种靶向纳米载体系统，将药物直接输送到骨骼，这克服了腺苷在血液中快速分解和其他脱靶效应的一些挑战。

研究人员还在研究如何使用这种疗法来减轻骨科手术和受伤后的疼痛。阿片类药物成瘾危机促使许多研究人员寻找替代品，她发现这种疗法激活了一种提高疼痛耐受阈值的途径。

创新关键点

这种新型绷带可植入骨折部位，并利用身体产生的腺苷将其保持在受伤部位以加速自然愈合过程。

创新价值

该新型可注射系统将使初级保健医生和其他医疗保健提供者能够对骨骼愈合受损和创伤性损伤的患者进行治疗。

The development of new biomaterials can accelerate the body's self-healing process

Varghese, the researcher, found that adenosine, a biomolecule naturally produced by the body, plays an important role in stimulating bone growth. The team has since designed a bandage for surgeons to implant at the site of the fracture, using adenosine produced by the body to hold it at the injured site to speed up the natural healing process.

On top of this, researchers are also working on a non-hormonal small-molecule drug that activates the same biochemical receptor to treat bone loss associated with osteoporosis. Different with current treatment methods, the current slow bone loss, and the team test of drugs has been shown in animal studies to reverse it and stimulate the body's ability to rebuild bone.

Research team has also developed a targeted nanometer carrier system, the drug directly to the bone, it overcomes the adenosine in rapid decomposition in the blood and other off-target effects of some of the challenges.

Researchers are also studying how to use the therapy to reduce pain after orthopedic surgery and injury. The opioid addiction crisis has prompted many researchers to look for alternatives, and she found that the treatment activates a pathway that raises pain tolerance thresholds.