创新背景

自然科学的发展离不开众多在动物身上做出的实验，英国动物学家William M.S. Rusell和微生物学家Rex L Burch在1959年出版《人道实验技术原则》，提出动物实验应该即减少实验动物用量，采用代替方法不用动物或其组织器官进行实验研究，优化实验技术和过程，减少对实验动物的伤害，总结而成“3Rs原则”。

创新过程

瑞士的制药技术在全球处于领先地位，用到的实验动物数量巨大。2019年瑞士成立了一家从事创新药物测试方法的公司Nagi Bioscience，专门研究生物芯片技术对于药物测试创新的作用。

生物芯片技术又称基因芯片技术，顺应基因研究和分子生物学的发展而产生。通过缩微技术，根据分子间特异性地相互作用，将生物大分子分析过程集成于硅芯片或玻璃芯片表面的微型生物化学分析系统，对细胞、蛋白质、基因及其它生物组分进行准确快速的检测。

Nagi Bioscience利用生物芯片技术，将微控流技术和微型蠕虫相结合，开发了用于测试药物效果的新型蠕虫。微流控技术运用的容量、体积和能量消耗都极度微小，能够精确控制和操控微尺度流体，在芯片领域应用广泛。

研究成果证明，新型蠕虫与人类基因的相似度高达45%至50%，与人类的某些遗传病基因也有颇高的相似度。新技术可以利用环保低能耗的方法代替传统的动物实验，符合“3Rs原则”，减少动物生命损伤。药物效果测试和安全性测试结果仅需几天就能得到，大幅度降低制药乃至科学领域研究的成本，

新技术将生命科学、生物芯片技术和微控流技术创新结合，为制药、生物研究和化学实验等提供了新的实验测试方法，绿色安全发展。

创新关键点

生物芯片技术创新结合微控流技术和微型蠕虫，开发替代实验动物的新型蠕虫，为制药提供新的测试方法。

Innovative use of biotic chips to develop new worms to test drug effects

Switzerland is a global leader in pharmaceutical technology and uses a huge number of laboratory animals. In 2019, Switzerland established Nagi Bioscience, a company engaged in innovative drug testing methods, specializing in the role of biochip technology in drug testing innovation.
Biochip technology, also known as gene chip technology, is produced in response to the development of genetic research and molecular biology. Through microscopic technology, according to the specific interaction between molecules, the biomacromolecule analysis process is integrated into a micro-biochemical analysis system on the surface of a silicon chip or glass chip, and accurate and rapid detection of cells, proteins, genes and other biological components is carried out.
Using biochip technology, Nagi Bioscience combines micro-controlled flow technology and miniature worms to develop new worms for testing the effects of drugs. The capacity, volume and energy consumption of microfluidic technology are extremely small, and it can precisely control and manipulate micro-scale fluids, and is widely used in the field of chips.
The research results show that the new worm is 45% to 50% similar to human genes, and it also has a high degree of similarity with some human genetic disease genes. The new technology can replace traditional animal experiments with environmentally friendly and low-energy-consumption methods, in line with the "3Rs principle", and reduce animal life damage. Drug efficacy test and safety test results can be obtained in just a few days, greatly reducing the cost of research in the field of pharmaceuticals and even science.
The new technology combines the innovation of life science, biochip technology and micro-controlled flow technology, providing new experimental testing methods for pharmaceuticals, biological research and chemical experiments, and green and safe development.